Epson stylus DX4450 i have changed the ink and the ink button the red light is still on and it will not let me print?

Did you use Epson Genuine Cartridges?
Epson Requires Genuine Epson Cartridges. !!!!!!!!

In Purchasing Epson's CX 5400, CX4600, & CX7400 and more, I found out that Epson does not like Generic Printer Cartridges. That sounds like your problem. Also in Purchasing the Brother's . Color that should be Yellow, will turn out Green, Blue Brown, etc.
These printers have a chip, that will detect if it is Generic or Genunie. When using Generic Cartridges, it will print lines thru the words, stripes across the picture and also do a mix match with the colors.

That's what these Companies do., so they can keep selling the ink cartridges. Some Printers, are able to use Generic, but you have to fill them up yourself and I heard, quite MESSY.

So I learned, thru trial and error, that you must use the ORIGINAL Genuine Cartridges for these PRINTERS. Some people say some models work fine compatible, but not mine.......

I had to replace the printer, but Epson, Lexmark & Brothers are always on sale. My Brother & Epson cost me $50.00 with Rebate. Don’t waste too much ink in cleaning it.

This is the only advice I can give you. If you find this helpful, pls rate me.

Thanks and Good Luck :0)