Key board and mouse are not responding

pls clear cmos jumper first. after power on and go to bios by press the key board key. if worked, pls check the O/S setup or recovery setup . pls select select system restore and press restore previous date.
if not working usb key board and install PCI or PCI X usb adapter and plug to key board and mouse to it and go to bios and disable on board usb controller.

go to O/S and check

It sounds like you have a board that is not booting at all. Remove everything from the board except the system RAM and CPU and switch it on. If it boots now, shut it down and then replace each individual item one at a time, booting the machine after each item is refitted/connected until you fit something that prevents the machine from booting. Pay special attention to system RAM sticks by removing them/it and refitting it as bad connections in the RAM socket can also cause a boot failure but removing and refitting the sticks usually cures this issue.

under the key board and under the mouse is a very small reset hole. reset key board first then mouse while computer is on.
hope this helps.

Improper boot media means it's not seeing your hard drive. Check hard drive ribbons and power connectors. Your hard drive might have failed if the ribbons and power connectors are installed properly.

Try hitting your capslock key (which will light up) or command-tab (which will switch between applications) to see if the keyboard and computer are still responding when this happens. If so, it sounds like the mouse or the USB port it is connected to may unfortunately be failing. 
Also, try connecting the mouse to another USB port as others have suggested, either on the keyboard or computer itself, as this will help you determine if the failure is in the mouse or port.

Do you get video at least?
Do you get keyboard during POST? (Try turning the system off, turn it on and keep hitting F8 until you get to a windows boot selection screen)

Does Windows boot all the way up but you just cannot interact with the laptop? Try plugging in an external mouse/keyboard/speakers, or remove it from the docking station if it is attached to one.
If you get keyboard/mouse before windows (able to move up and down the boot selection screen), then Windows may just need to be reinstalled for some strange reason.

If you still aren't getting anything, the motherboard may need to be replaced.

Press and HOLD the Power button for 5 seconds ...this will turn off computer ......her's a list of beep codes http://www.computerhope.com/beep.htm

These may help !

Try a different keyboard /mouse if you can /make sure NO pins are bent or missing on PS2 connection .....

When booting up computer hold the DEL key down this will take you into the BIOS.......Select LOAD DEFAULTS usually F10 ...you'll see it on bottom of screen .....Save when prompted and see if it boots......Good luck

try to change other keyboard. or its may be the motherboard provide other f key to startup the CMOS setup.

if its laptop there is a button that locks the keyboard and mouse just look for the sign that locks and unlocks the keyboard and mouse.

try plugging in an external keyboard & mouse, hopefully that should work