My 04 Town & Country has a loud Knock in the motor

Think you have the progression of the problem backwards. Likely the engine got hot and began knocking...THEN your wife put too much oil in there to correct it but that did not work. Do not drive it and have it towed to a shop, or, put an external oil pressure gauge on it and check pressure. Likely you either had an overheat due to a coolant problem or due to a bad engine bearing. Either way, I'll bet you have little or no oil pressure and pretty likely you need an engine. (replacing bearings is an option but generally they will fail again soon after the repair is completed)

Why did the engine get hot? Coolant loss? Was the oil level too low before more was added? If it was low, how many quarts should have been added? I believe you have serious engine problems. Too much oil is as bad as too little. What happens when it is overfilled, is the oil 'foams', causing a lack of lubrication of internal components. Oil in a foamy state will not lubricate properly. I believe what you hear is a crankshaft or rod bearing that is now damaged. If I'm correct, you need to replace the engine. Sorry for the bad news.