For Toshiba Satellite Go to control panel>Hardware & Sound>Mouse>Device Settings Tab... go down to where there is a box to check that says something like "Disable touch pad when external mouse is connected." At least that's the way it is for mine.
Hope that helps.
Internal mouse? if you mean the touch pad or that red ball thing thats in the middle of our keyboard, then i don't think you can turn those off. try going to Start>Control Panel>Printers and other hardware. maybe the option will be in there. if you want to use a wireless you need the USB "thing" and plug it in your laptop. you might have to put in a CD and install it first.
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