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It depends on which version of Rock band you are playing, Rock band 1 will not work with Guitar Hero guitars at all, but Rock Band 2 on the wii will except them. and for the microphone you have to have a seperate wiimote sync'd up tho count as the controller for the the game to recognize the mic.
You plug the hub into the back of the wii, and then plug the guitar (and mic) into the hub. If you just want to use the guitar, it doesn't matter if you use the hub or not. The hub is pretty much just to make life easier because there are only two ports and rock band requires at least those 2.