Virusdefs is where your antivirus has placed the virus definition files. Normally you would not move them.
The size however concerns me.
It may be that your antivirus had not deleted the older ones. In that case I would check inside the folder and maybe check the dates on the files.
1. If there are a lot that are quite old then CUT & PASTE them to another location.
DO NOT DELETE THEM YET.
2. Shut down and restart your computer and watch for any error messages from your antivirus. Take note of them if there are, esp. any file names.
3. If there was an error then fo find that file in the location you just moved them to and move that file (or files) back
4. Then shut down and restart again. If all is good then run your antivirus and make sure it all still works. If so then you are safe to delete the files you moved If not then go back to step 3.
I know it may look a little like a long way round but you do not want to compromise your antivirus !
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