Enable macros in the Backstage view Another method to enable macros in a file is via the Microsoft Office Backstage view, the view that appears after you click the File tab, when the yellow Message Bar appears. Click the File tab. In the Security Warning area, click Enable Content. Under Enable All Content, click Always enable this document's active content. The file becomes a trusted document.
SOURCE: Game Embedded In Excel 2007 Won't Play
You are better off not playing the game as they usually contain some form of malware.
To possibly infect yourself you by playing the game will need to change the security settings for macros in excel. This is usually located in the Tools menu. Set it for the least restrictive setting, but you have been warned, you will be infected with malware. If not with this game then in the near future.
SOURCE: i am using microsoft excel
From the excel help file
Excel Workbook
.xlsx
The default Excel
file format. Cannot store VBA macro code or Microsoft Excel 4.0 macro sheets
(.xlm files in Excel 4.0).
Excel Macro-Enabled
Workbook
.xlsm
Uses the same basic
XML format as the Excel Workbook, but can store VBA macro code. Users saving
an Excel workbook that has VBA code or Excel 4.0 macro sheets (.xlm files in
Excel 4.0) are prompted to use this file format.
Excel Template
.xltx
The default file
format for an Excel template. Cannot store VBA macro code or Excel 4.0 macro
sheets (.xlm files in Excel 4.0).
Excel Macro-Enabled
Template
.xltm
Can contain a
VBAProject part or Excel 4.0 macro sheets (.xlm files in Excel 4.0).
Workbooks created from this template inherit the VBAProject part or Excel 4.0
macro sheets that exist in the template.
Excel Add-In
.xlam
A supplemental
program that runs additional code. Excel add-ins use the Open XML file format
to store data, and they support using VBA projects and Excel 4.0 macro
sheets.
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