2007 lexus is250 radio turns on pop in speaker and then no sound

This is likely to be a problem with the amp itself and an internal component like a switching transistor. The only way to check is a two-fold test. An auto electrician with a pro grade scan tool computer to diagnose the full electrical system including the BCM which also runs the radio system. If that passes, the radio amp needs to go to an audio tech or the maker service centre.

The thumbing noise is an out put if you hear it over the speakers.
So that means the problem is with a CD or cessette player that you must have that will not pop back to the raido mode

If power is more than speakers can handle this will happen. If you have a amplifier in the rear than all it is a fuse or a circuit breaker needs to be reset

Take it to a stereo shop and consider rolling the repair into an upgrade to new speakers. They will test and if the radio / wires are bad just buy a new radio, etc.

Is it a factory amplified system? Could be the volume knob. Might try unplugging the radio for test purposes and see if it still pops and buzzes to get a better idea of where to go next

1st check fuse for Amplifier.

2nd if fuse is good, most likely the Amp has died. Common for GMC

check your installed speaker fuses, might be broked. if you are using or your vehicle is equipped with high powered amplifier then the speakers were secured with fuses to prevent damaging it.

I would change the starter.Remove it and have it checked where you are going to purchase the starter.

My 2007 Lexus IS250 is dead, hooked up a charger. Charger keeps shutting off. Triple checked the cables, + - correct, still shuts off charger?

speaker wire crossed sum wear ok