DVD drive not responding

My DVD drive won't open and when I go into My Computer and select 'eject' on the dvd drive it says:
"DVD RW drive (E:) is in use. Save any open files on this disk, and then close the files, or programs using the files, and try again."
...although I am not using the drive and there are no disks in it.
I have checked everything about the drive and it all says it is working normally, except that is clearly isnt.
I'm not sure if I need to replace the entire dvd drive or if there is another way.
Please help