Same problem. Bose CineMate light went red and

If resetting this system and re-seating the interface (box with light) to the bass module doesn't fix this, you may need a new interface module. This sells for about $40-50 from Bose. If this is under it's 1-yr warranty, they should be able to replace this for free.
So just incase you haven't tried it: 1. Unplug the power cord from the bass module (sub-woofer) along with the interface module and wait at least 30+ seconds. 2. Re-connect the interface first- screw it in as tight as can be. 3. Re-connect the power cord, and try the remote again.
This is really the only solution, and it's exactly what their tech support will have you try. That's the one functionally weak point with that system, that little module needs to be adjusted and re-seated from time to time.

cjack is totally right, this really solves the issue, beats me the system just wanted to broke , but after restartin it it works like a charm!. yesterday power went out here, so that might b the reason!

I too had the same problem. I tried the steps no go. I bought a new bose interface cable and I am up and running you can find them on ebay for a reasonable price.