This sounds like Microsoft issue. However you can try several things to try to solve it.
1. Please make sure that you have full admin rights on the PC, especially to the AppData folder, which is located C/:Users /User name/ AppData/
You need to grant accesses also to the folder Local, where all Dymo related files are stored.
2. You can try to re-install the Dymo Label Software by using the LWSupport uninstall tool, located in: C:\Programs\DYMO\DYMO Label Software\Support. Just double-click it to start the driver removing. Please note that before that, you need to close all running programs.
After that please delete also the Dymo folder under C:/Programs
Then navigate to C/:Users /User name/ AppData/ Local/ and delete Dymo and Sanford folders.
After you do that, you can uninstall the application from Control Panel/ Uninstall Programs.
Restart your PC and download the newest version of Dymo Label Software by clicking on the following link:
Please make sure, that the device is unplugged during the installation.
I hope this will solve the issue. If not please contact us directly :