Could you state what exactly you have attempted?
For firmware updates, go to
R4i's website and go to the "Download" tab. Download the latest firmware files, and put those on the root of your MicroSD card. Reattempt booting it up.
Another issue could be that the internals of your DSi have become dirty. Try cleaning the contacts of the game slot with a dry tissue, and attempt again.
Does your DSi load other games but not R4i? The R4i is probably broken. Check if you have any warranty and contact the R4 team. If the DSi doesn't load any games, attempt cleaning. If this still is the issue, the DSi is broken and you should contact Nintendo.
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