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Open the Device Manager, uninstall the Realtek from there. Restart the laptop and see if its automatically loads itself on Device Manager well good enough. If it doesn't then you would need to get the motherboard CD of the Acer Laptop and install the Realtek Driver.
Sounds like a hardware issue. I would guess that there is a bad connection between the usb's and the motherboard. If you are comfortable dismanteling the laptop and re-soldering the usb's than give that a try, but I would recomend you give it to a pro.
Here is a link that explains the process.
Is the DVD drive listed in device manager under CD/DVD drives at all? If so, remove it and reboot. Windows might be able to re-detect and reinstall the drivers for it, but odds are the drive is bad. You can try removing the drive from the computer, and use compressed air to blow out the area where it connects to the laptop. Also check the connection on the DVD drive to make sure there isn't any physical damage, bent pins, etc.
Right click the sound icon in the lower right of the screen, near the clock and select 'open volume control'. Next click 'options' and select 'properties'. Click 'recording' and make sure that 'mic' is checked. Make sur ethat it is not muted either.
I am worried that there is a problem with the sound card on your motherboard. If it has worked in the past and then suddenly disappeared, usually it is because the computer can no longer locate your sound card. It will not load a driver for a device that no longer exists. Since you have already done most of the troubleshooting steps, it is time to think about replacing your motherboard. Good luck
It sounds like you have not properly installed the audio driver. You have to go in device manager and see if you have any question mark in any of the devices or the audio. To go to device manager you hit start then control panel and then click device system and then click device manager.