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Yes. The case doesn't care what size the drive is. The computer is just asking for the USB driver for the case. Check the WD site for the driver for the model of MyBook that you have. That should cover it.
Does your drive make any unusual sounds like any of these: http://datacent.com/hard_drive_sounds.php ? If yes then you got a problem - it's something mechanical with the heads. If it sounds normal or doesn't spin up at all - try to connect it to another computer and if still no go - remove the internal drive from enclosure and connect directly to PC via SATA port.
Try first disconnecting all USB ports and power plug for half an hour, this will get rid of eventual problems caused by electrostatic charges on usb channels. If it does not work, this means that the virus has corrupted your Windows System, probably the root hub is defective. In this case you will have to reinstall windows, either using recovery, from disk or partition, or using a Microsoft windows setup disk. Save all your data before reinstalling.
Sounds like your drive may be faulty with the rattling - if I were you I'd back up everything off it pretty quickly, then send the drive back to western Digital if under warranty. I wouldnt open it otherwise your warranty will almost certainly be void.
See my response to someone else at the following link: http://www.fixya.com/support/t587080-external_hard_drive_not_recognized . Not sure if the WD My Book you are trying to open is the same as a 500G. Mine has a black case, resembles a book and measures approx 7" high x 5 1/2" deep x 2 1/4" thick. I was able to open my WD My Book 500G drive but not w/o tearing up the rubber around the edge. Once I got it open, I discovered that there are tabs at the top and bottom of the case. The tabs are recessed w/i small rectangular holes and hard to see unless you look at it w/ a bright light. The tabs are located about 1 inch from the front edge of the drive on the top and bottom. It appears that you have to depress both tabs w/ flat tip screw drivers (or some other similar device) while pulling on the sides of the casing - you almost need three hands (maybe even more) while trying to get it open. The rubber around the edges fits tightly so it is extremely difficult to pull it apart w/ the rubber still in place. There must be some other trick to opening the case but I'm not sure what it might be. Not sure what you can do once you open it unless you have another drive that you can swap parts w/.
Good luck. Let me know if you figure out how to open the case w/o tearing up the rubber.