2007 Escape Hybrid Was making very loud rattling noises, started to pull over to shoulder of freeway and vehicle started de-accelerating. White smoke billowing out the rear. Pull over safely now and service transmission messages came on.

SOURCE: 04 Endeavor rattling noise

I had the same problem! I crawled underneath the car and discovered that a heat shield on the exhaust header pipe was corroded and rattling against the exhaust pipe. (Before the muffler)
I removed the portion and clamps and solved the problem. Give it a try.

SOURCE: Loud ticking/knocking/rattling sound when I start/accelerate

hi is it miss-firing as it sounds like a knocking noise can be anything but if you can feel it on the accelerater pedal then the noise sounds like its on the inlet valve side which would transfere the noise up the throttle body where the accelerater is located it could be something as simple as a tappet come loose to a burned valve you need to have a look do a compression test and take the rocker cover off see if theres anything come loose yates210456

SOURCE: Honda accord 07 making a highpitched squeaking noise in cold

That Squeeling is your Belt. You may need a New Belt Tensioner to keep it Tighter. As a Quick fix, Go to your Auto Parts Store and get a Can of Fan Belt Dressing and spray this on the Belt and it will be Quite for a while. Please Rate my Solution, I need all the Help I can Get! Thanks!

SOURCE: engine or transmission knock / rattle upon

I had the same problem on my 2006 Lucerne and it was the engine mount located on the front of the vehicle behind the radiator.

SOURCE: Loud rattling noise while accelerating

First thing i would try...... ISOHEET, Red bottle..... allows water to be mixed into the fuel and be burnt out of the tank.
get a good qaulity fuel injection cleaner, if you can locate the brand MALCO, i found it quite succesful..... and go with a full tank of premium fuel such as ammoco or shell......do not use yellow bottle of heet

Testimonial: "Might be water in the tank?"