Question about Medical
I m 76 yr female. my left knee jointreplacement opration due 15 aug/13.doctor injectd me 3 injection of metadac-50 1/per week.is it useful for me? n what is its side eefect? 1 injection will be due next week
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Posted on Jan 02, 2017
Metadec 50 is a type of anabolic steroid (AAS).
The immediate effects of AAS in the brain are mediated by their binding to androgen (male *** hormone) and estrogen (female *** hormone) receptors on the surface of a cell. This AAS-receptor complex can then shuttle into the cell nucleus to influence patterns of gene expression. Because of this, the acute effects of AAS in the brain are substantially different from those of other drugs of abuse. The most important difference is that AAS are not euphorigenic, meaning they do not trigger rapid increases in the neurotransmitter dopamine, which is responsible for the "high" that often drives substance abuse behaviors. However, long-term use of AAS can eventually have an impact on some of the same brain pathways and chemicals-such as dopamine, serotonin, and opioid systems-that are affected by other drugs of abuse. Considering the combined effect of their complex direct and indirect actions, it is not surprising that AAS can affect mood and behavior in significant ways.
Steroid abuse can lead to serious, even irreversible health problems. Some of the most dangerous among these include liver damage; jaundice (yellowish pigmentation of skin, tissues, and body fluids); fluid retention; high blood pressure; increases in LDL ("bad" cholesterol); and decreases in HDL ("good" cholesterol). Other reported effects include renal failure, severe acne, and trembling. In addition, there are some gender- and age-specific adverse effects:
Posted on Mar 08, 2011
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