Error that wont go away

Please be careful when running any sort of tools on the registry. Since almost everything in windows has a registry entry you MUST be very carefull when doing anything to the registry.

IMPORTENT : Back-up the registry BEFORE doing anything to it.

The problems you are having right now COULD be because of changes made to the registry. It is hard to know because you didn't post EXACTLY what the error messages were.

I can only guess what happened:
1) Possibly references to .net driver paths where re-written or deleted, A re-install of windows .net should fix this problem.
2) The path to your outlook inbox files could have been rewritten and/or possibly deleted. If you cannot find the path to these files (if they are still there) and enter that path in to the registry, then you have probably lost your local copy of your saved email.
In that case there is no fix.

My recommendations:

1) Always back-up, back-up, and back-up some more (you never know when something will go wrong)
2) Always take note of the exact error messages the computer gives you. It is THE only solution to any problem.

Also to save you panicking, most of the registry entries regcure reports on (as with ALL registry repair tools) are NOT a problem. MOST of these entries are MRU entries (recent files applications remember), missing shortcuts, directory's and the like, nothing of which will harm your computer. You really only need to run a registry cleaner once every few months.