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If you getting this error then you won't be able to open computer in safe mood, Because this error message indicate that there is no proper bootable media selected or there is no OS in your Hard drive. First thing you can do is go to BIOS and check what is your First boot device selected, if it is other then Hard drive then change it Hard drive and save setting and come out of it. If there is any media, like Pen drive or any CD then remove it and start your computer. If still you have same problem then I am afraid that your OS is Corrupted.
Do you have any extra things plugged into the usb ports? (external hard drive,Ipod,Flash drive) anything like that can sometimes cause pc's to hang at boot they will try to boot to that device instead of your hard drive
You will need to perform a repair install using a Windows CD. The current configuration on the hard drive was basically with an entirely different computer and thus, it does not know how to "talk" to the new hardware. The repair install should fix that and create a new Hardware Abstraction Layer (HAL) that will enable Windows to "talk" to the new hardware.
Run hard drive tests, if HD tests good, and no data to keep, restore os from restore partition with f10. If data needs kept, run a repair installation of os. Run fixboot and fixmbr commands from prompt. Also try sfc/scannow from command prompt.
0141 error is no hard drive detected. So boot to the BIOS F2 at boot and ensure that the BIOS is seeing the hard disk drive. If it is not, then reseat the drive/drive cable connections and try again. If the drive is detected in bios, then try booting to WIndows, if HDD never is detected, reset bios defaults and reboot, and see if it detects, if still not detected, replace the hard disk drive
Click Start>Run and type msconfig. Select the startup tab and deselect everything. Reboot your computer and attempt to log into Windows. If you are successful you will need to access msconfig and re-enable programs systematically until you find the culpret.
There's a possibilty that there are some bad sector on the hard drive, so in order for you to restore the hard drive you may need to reformat it and reinstall the opearting system for as long that the hard drive is still detected by your BIOS computer, if hard drive is still detected by your computer BIOS and you have the operating system installtion CD you can go ahead reformatting and reinstalling everything back...