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First are the batteries good?
Turn the mouse over and find the small rest/connect button
on the bottom of the mouse and press it. This should connect the mouse to
the receiver and work properly. If not, try pressing the receiver button
and then press the button on the mouse. This should be done whenever you
change batteries or glitch. Hope this helps you. Bud
The mouse worked initially....have you tried doing a system restore back to a few weeks ago to see if that solves the problem.. With Vista and so many of it's incompatibility issue's...you maybe have downloaded something and it corrupted your software for that mouse...
Here is the url with vista drivers. Redownload the drivers and install...see if this helps