Using HP 5300C scanner with Windows ME for years.
Are you still on ME? Might be time to step up to XP or vista, nevertheless, try this.. works great on my XP pro and Vista with some tweaking, but straight forward with XP Pro. Good luck!
Does it show up in your hardware profiles? What does it say on details when you right click the scanner? When you installed the driver, was it before your plugged in the USB? You may have to uninstall and reinstall it again, this time use the one from HP's website with any patch if applicable.
http://h10025.www1.hp.com/ewfrf/wc/softwareDownloadIndex?softwareitem=sj664en&lc=en&cc=us&dlc=en&product=58381&os=228&lang=en
If you have successfully used it in the past, follow the install prompts and restart.. instead of using the products software, use Windows included scanning program which is much better than the proprietary one designed by HP. As long as you have the proper driver installed your system will know how to apply it.
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