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Check the the connection cables to the CD/DVD drive inside the computer (make sure they are seated). Enter the BIOS using the DEL or F1 key at startup and make sure the CD/DVD drive is detected. If not, try replacing ribbon or sata cable going to drive.
When you open my computer do you see the drive in the window? If the drive does not show up in this window you can check two things, check to be sure that the cable connecting the drive to the mother board is good. And the other issue could be that the drive itself has gone bad. If it is unable to read any cd's then you probably need a new drive. Be sure to put in several cd's to be sure it is not the cd disk.
First go into Setup (usually F1,F2 or del) at start-up. See if your drives show up there. With Windows running, right click My Computer, left click Properties, left click Hardware, left click Device Manager, left click DVD/CD-ROM drives. Also check IDE ATA/ATAPI controllers. Do the drives show up there? If they do right click on drive and left click Update Driver. If they are not there go back to System Properties and left click on Add Hardware Wizard. This will search for devices. It may ask you to insert Windows CD which of course you can not do because the drives don't work. Try a different drive. When you cleaned out your computer did you delete or uninstall Office? That may be what caused this problem. None of this may work but it is a starting point.