I... would not. From what I know most tires have a direction of rotation which is a result of the overlap of the belts when they are applied. Then the rubber is put on top and a tread is lay in the rubber. The tread on the front (used primarily for stopping) is often different from the tread on the rear (used primarily for moving). Basically they're designed to accomplish different functions, and while they may work anyways, it will not work as well as it could.
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