I'm not sure if this will work on the lide 20. I have an lide 35, and there are no 64 bit drivers for it. I downloaded and installed the drivers for the lide 60, told the computer to manually find the lide 60 drivers for my scanner, and installed the canoscan toolbox for vista 64 bit. Works like a champ.
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your scanner could be a 64 bit and your computer is only 32bit follow this to verify if your computer is a 32 bit or 64 bit system
1. click start menu
2. right-click MY COMPUTER
3. click PROPERTIES
4. from the properties window you will see if your computer is a 32-bit or 64 bit system
32 bit won't work on 64 bit system
Unfortunately, it doesn't look like Canon supports this scanner under Vista. Check if the Windows generic TWAIN scanner driver will work. The Canon software won't work. If the generic driver can be installed, then you should be able to acquire scans in Paint (File > Import from Scanner or Camera), Windows Fax and Scan (New Scan) (some versions of Vista) or Windows Photo Gallery (IIRC it works like Paint).
I hope this helps.
Cindy Wells (Canon wants you to upgrade. I have a different scanner that isn't officially supported past XP and the generic driver works fine. Unfortunately, you can't just use the XP driver in the compatibility mode due to the lack of signed drivers that are required in the 64-bit OS)
Go to the following URL: http://www.usa.canon.com/consumer/controller?act=ModelInfoAct&tabact=SupportDetailTabAct&fcategoryid=235&modelid=11446#DownloadDetailAct
Then select your OS.The drivers and software for Win7 32 bit and Win7 64 bit different. The Win7 64 bit drivers are digitally signed; the 32 bit version doesn't need the same level of security certificates (a Microsoft issue).
QUICK ANSWER: use the original USB cable that came with the scanner.
LONG EXPLANATION: Using Vista (32 bit version) and a Canon N670U scanner with the new drivers installed from the CanonUSA website. This driver is works for Canon scanners: LiDE 20, LiDE 30, N670U, N676U and N1240U, found at http://www.usa.canon.com/consumer/controller?act=ModelInfoAct&tabact=SupportDetailTabAct&fcategoryid=235&modelid=6625
Canon says it doesn't support Vista 64 bit version. I couldn't get the scanner to work and kept getting the TWAIN error also, despite uninstalling / reinstalling the driver. Finally, decided to disconnect my 3rd party 16 foot USB cable and use the original cable. I swear, it WORKED! I can't explain why, but it did. Perhaps there is increased resistance, hence reduced power going to the scanner by using longer/different USB cable? Anyhow, it worked...go figure. If you have the 64 bit version of Vista, I guess it won't work(?).