Grand Theft Auto SanAndreas

Grand Theft Auto: San Andreas also uses Securom copy protection software.

Please read the below mentioned. The same solution which I had posted for the game Juiced.

The solution is the same for all games using Securom copy protection software.

Securom is a copy protection software that sometimes conflicts with any background applications,multiple disc drives, virtual drives, USB storage devices (Pen drivesand USB Hard drives).

This however can be solved once you submit a analysis file to the Securom Support.

To extract the Analysis file you can follow the below mentioned.

Open Game folder
Locate "GTA_SA.EXE" file and then right-click on it context menu will appear
Select "Launch Analysis" within that menu
After the selection a disclaimer window will appear on your screen, to proceed, click the "YES" button
This 'analysis' will now generate an 'AnalysisLog.sr0' file within the root directory your C: drive.

Go to your "C" drive to locate the "AnalysisLog.sr0" file and zip the file compression utility programs such as WinZip, Winace or Pkzip

-Submit the Zip file to: support@securom.com for evaluation along with "Grand Theft Auto: San Andreas " in subject line.

Securom support will then analyze the file for conflicts and send you a new executable file. Once you have the new file, extract and paste the executable file in the root directory of the game.