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Most current high-performance graphics cards (GPUs) are PCI Express (PCIe) cards. The others use the "legacy" standard known as AGP.
ML350 G5 has PCIe slots, but they are x4 or at most x8 variety: most high-performance GPUs require a PCIe x16 slot. Of course, PCIe cards are supposed to work with lower-bandwidth slots too, but that limits the performance of the card. I would not expect high-performance GPU manufacturers to do much testing with limited-performance configurations, so you would easily find yourself in the land of "unsupported".
PCI-X is a faster/wider version of PCI for servers: I don't know of any common high-performance graphics card that would use a PCI-X slot.
PCI-X is backwards compatible with plain old PCI, but I would not call any PCI graphics card "high performance" today.
Most high-performance GPUs also require more current than a standard PCIe slot can supply. That necessitates an extra power feed from the PSU to the card, but such a power feed is not often available in server-style machines.
Trying to convert a rack-mount server into a graphics monster machine is like trying to adapt a Formula-1 car for a gravel-road rally: different roles call for different designs.
Onboard card needs to be activated in CMOS/BIOS/Setup...
Contact the manufacturer of the computer & request they walk you through if you don't know how to do it or if you're not comfortable doing so...
... Should be under Onboard Devices and/or have a title similar to "seek AGP/PCI/PCI-E" first on boot.
Sit down and boot to Setup. Don't be preoccupied with anything else and if you are distracted, remove your hands from the keyboard before your eyes leave the screen. Don't save any changes unless you are sure and note all changes you make on paper. If you accidentally change anything, exit out without saving changes and start again. F10 to exit saving changes, Y for yes and Enter.
If you only change what I describe, you should have no problem booting. If you wish to change something else later so be it, but don't do it unless you have support. Changing anything having to do with voltages, data speed, fan sped, etc., (overclocking) can cause components to fry and then you'll have nothing but a parts computer, if it doesn't everything.
Could be power supply failure. They have cheap power supply testers on eBay and at local computer retailers. They also have Motherboard testers. If you changed anything with the system you can't expect people to know so please specify what it was you changed and everything you've changed. If you went from an onboard video card to an add-in graphics card, you will most likely have to enable the card in BIOS/Setup. Do not change anything is this area unless you know what you are doing. You can completely fry components and/or start a fire. A PC case contains many fire accelerants so changing voltages or anything that remotely resembles overclocking is not only pointless, but needs to be done with complete awareness of what it is you are changing and what the result of performing the action will be.
Yes this can be done and the only limit on size is the drive size. The current max size for mainstream drives is around 2TB so make sure the adapter will host more then one SATA ports as at least 2 drives will be required.
Also make sure the adapter card will work with the Operating System as many are designed to be used under Windows only so if you are running Linux or BSD, there may be no support. The other limit is the fact that the PCI is not a fast bus by current computer technology standards. If there are additional PCI devices such as network interface cards, integrated graphics, modems, soundcards, game controller adapters, USB expansion ports, Firewire expansion ports, etc.. theses devices will all be sharing the bandwidth of the PCI bus, leading to slow read and write performance of the additional storage.
If you are adding these drives to have fast storage, I suggest saving the money for a new system that makes use of current technology.