I just purchased in 1999 Honda CRV DX, it had been sitting for a couple of years put fresh gas in plugs and changed oil, and it is running a little rough still. I'm thinking of doing new wires .'

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Change the gas filter. If car sat for 2 years without being started, the gas could be stale Put fuel system cleaner in gas tank. The car may need a double dose.

Change the gas (and the oil, with Synthetic). The gas loses it's volatility after just a few months and starts to go bad. Siphon all the gas out and put in a fresh tank. Let us know if that helps.

if it is posible for you to drain the the old gasoline out and refill the tank with fresh gasoline that would be great, but if you only have a1/4 tank and draining the tank is not posible fill your tank up with supreme gas not regular the better grade gas with the high octane will dilute the old gas and help burn off the gas when the car starts.if you have more then 1/2 a tank try to pump out the gas with a driil pump, you can buy these a your local hardware store insert hose in filler neck of the tank.you should also remove the spark plugs and with and oil can add 8 good pumps of the can of motor oil in the cylinders do not replace plugs **** with a freshly charged battery turn the engine over few time in 2 or 3 second intervals this will kleen any rust that would have built up on the cylinder walls and also lube up the cylinder wall so that at start up the cylinder wont be dry ,add a few more sqirts of oil between turnovers.Replace spark plug if old ones look bad put spark plug in and start her up its going to smoke a bit at firts **** it will stop after the oil that was put in the cylinders burns off,let the engine idle for 10-15 minutes before putting any strain on motor give it a chance to clean out cylinders burn a few tanks of gas and change gas filter it should be fine.

After sitting for 2 years, the gas has moisture/water and it's pretty much not gas anymore. It's like your car needs 87 octane and you are running on 80 octane, just enough to fire off but not strong enough to to keep a good idle/firing. I would drain all the gas out and use a higher octane gas for a half of tank just to clean the lines and injectors. Fill the tank up 1/2 with high octane and use a bottle of injector cleaner. This should clear up the sluggish problem. Also it's a good idea to change the oil and run an engine cleaner through. Drain a quart of oil, and pour in the engine cleaner. Let engine run for about 5 min for oil to heat up and circulate. Drain oil and change oil filter, put in new oil.

change the spark plug's

If it has been sitting for 3 years it could be a number of things. First thing to try is a good tune up (plugs, wires, oil change, air filter, and fuel filter). If the plugs have fouled out they are not getting enough spark to burn the fuel. Also if the fuel itself has turned, you should try to drain the tank, this is not feasible at times and can be substituted by adding as much fresh gas as possible and a can of Octane boost/ Gas drier. SeaFoam is what I would recommend (found at your local autoparts store. If you have over half a tank of gas that has been sitting that long, you will need to find a way to drain what is in it. There are a few tricks to doing this without dropping the gas tank or sucking it out with a garden hose. Try the tune up first though.

check air filter, spark plugs andfuel system

It could be the voltage regulator trying to charge a dead battery. (It could burn out if you keep doing this)

Or it could be a lifter noise, rust on the belt pulley from sitting in one position for two years.
Buy a good battery, change the oil and put some fresh gas and fuel stabilizer. It might be nothing serious!

try changing the main relay under the dash