My engine light came on the computer said it was1&2 cylinder was mis firing it's a 2001 ford escape v6 4&4 what could it be

Pull the spark plug of cylinder 2. Put the coil on the spark plug. Ground the sparkplug and have someone crank the engine. See if you see a spark. If you have no spark switch coils with another cylinder. If still no spark it could be one of the wires going to the ignition coil. If there is a spark do you smell gas at the spark plug hole? Could be no fuel to the cylinder.

Check engine light on ? Code's ? What engine ? 2.3 l 4cylinder or 3.ol v-6 This vehicle has coil on plug ignition system , not coil packs ! a coil per cylinder . If new coils an still has no spark , has no B+ voltage to the coil or the PCM isn't controlling them . Without testing i'd only be guessing as to the problem .If the repair shop you had it to can only say it had to be the coils , I'd find another shop to take it to !
Autolite Coil on Plug Ignition troubleshooting

Not good

With any luck, you didn't ruin the drivers
in the PCM

For the future--you never ground any ignition
coils or modules.
If you insist on testing that way,you use the
proper tools/acc's for that

You don't even hook up a volt meter with the key on.

PO0351 thru PO356 Escape 3.0 lt

1-A
2-B
3-C
4-D
5-E
6-F

Replaced the MAF sensor - nothing. Took it to a authorized toyota shop & checked compression which check out good and put the computer on. Computer read mis-fire on cylinder 1, and then multiple misfire (like it would jump around). We went ahead and replaced the fuel injector on cylnder 1 - did not solve problem as when we hook the computer up, misfire seemed tp stay at idle and seem better when running high RMP, but check engine light is on as it never went away. Went ahead and replaced the coil pack to cylinder 1 - nothing. what am i missing?

Replace the spark plug and if the problem still exsist replace the the ignition wire to the #4 cylinder.

you have bad coil packs. did you change the coil packs?

2001 Ford Expedition 4.6 liter V-8 VIN "W"




2001 Ford Expedition 5.4 liter SOHC V-8 VIN "L"




Hope this help (remember comment and rated this).

If the engine has a P0305 DTC (Data Trouble Code) for a "cylinder 5 mis-fire detected", then the first thing to do is to do a compression test to determine if the mis-fire is actually being caused by a mechanical problem, or an electronic problem.

If the engine really does have low compression on the #5 cylinder then that is caused by a mechanical mis-fire and nothing electronic will repair it, and the most common causes for a mechanical mis-fire would be a burnt or bent intake or exhaust valve, a warped cylinder head or damaged head gasket, or a damaged piston. You can call around and find a repair shop that will do a "compression leak down test" if you want to know exactly what is causing the compression leak without any dis-assembly to the engine.

Ford V6's - rear bank of cylinders are 1 - 2 - 3. Front bank are 4 - 5 - 6 starting from passenger side (front) of engine.
Your firing order is
1 - 4 - 2 - 5 - 3 - 6

You're welcome.

sounds to me that you have a vacume leak at inlet manifold