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Check spark plugs, leads, distributor cap & rotor arm, fuel pump, fuel filter, coil pack(s), relays, replace any items that are suspect IE Fuel filter which has probably not been changed since new even though they should be changed on all vehicles every 18 months, all of this can be done at home & will save you a lot of bucks in mechanic/garage fees,
Very odd. A Google search comes back with lots of "Duramax" hits . The code is: "Fuel System Leak Detected - Large Leak" Some fixes that I found were replacing the fuel filter, others changed the FPRV (Fuel pump return valve?) When you're pulling a trailer there is a much greater load (air resistance) even when just cruising. Empty or fully loaded, it's mass won't matter, it's the extra fuel required at every phase of your drive. If the fuel filter is getting clogged, it's possible that some sensor is showing a pressure that is beyond predetermined limits. Try the fuel filter replacement first to see if that fixes it.
duramax diesel trucks do not have a lift pump. start with the simple things make sure your fuel filter is tight and check the shreader vlave on the fuel rail if that don't help check the filter housing for a leaks arround the heater element or a crack in the housing itself
whens the last time you changed the fuel filter? ther maybe to much water in the filter and the tank, on warmer days the fuel maybe trying to seprate in the filter, when you go to start it you maybe trying to run it on water more then diesel. add a cetien booster to the tank of fuel you have see if that helps
IF THIS IS AN 2007 YEAR THE FUEL PUMP SHOULD BE IN THE TANK. IF THIS IS A DEISEL THE PUMP COULD BE ON THE FRAME RAIL BUT ONLY HAS ONE PUMP THE PUMP RUNS BOTH TANKS.
CHECK FOR ANY CRACKS IN THE FUEL LINE ALSO. BUT IT SOUNDS LIKE THE FUEL DRAINS BACK INTO THE TANK WHEN IT SETS THIS IS A SIGN THAT THE FUEL PUMP IS NOT HOLDING IT'S PRIME AND THIS NEEDS TO BE REPLACED