Have a 2003 e250 ford van misfiring i changed the plugs the coil and the plug wires still missing

Start by replacing coil and spark plugs for cylinders number 1 and 3 . That would be 1st and 3rd cylinders on drivers side . TIP OF THE DAY
ALWAYS SPRAY SOME WD40 DOWN THE Hole so the spark plugs come out easily.
Good luck

misfires are also from faulty injectors and low fuel pressures. from what you state I would be looking at those areas for the problem.

week injector

you don`t say how you verified that the plug and wire was good. I think these use coil on plug, if so check powers and grounds for that coil as one may have a problem.other things that could cause this is a bad fuel injector, poor compression due to either rings, valve, worn cam, damaged push rod,

Then you went to a shop that doesn't have the
skills necessary to resolve much,cylinder misfires
in your case

You never need a MIL Lamp, to check for codes,cylinder
misfires & other data

Probably coil pack. Follow spark plug wire from spark plug to where it plugs in, that is your coil pack.Some are seperatable. Depending on motor size you may have coil over plug. You said wires not (cop) coil over plug boots.If it is coil over plug it is just a boot you changed in that case the coils plug into boots & on plug & an electrical connector. They are seperate for each cylinder.

you have to remove the engine shroud inside the the passenger compartment. its the cover between the 2 front seats, it covers the back 1/2 of the engine once its off you can see the entire engine almost

is there a check engine light on? if so what the codes?
this could possibly be a coil misfiring you should have this scanned, and tested for a misfire.

Yes also get the distributor checked thoroughly. Its contact points might be worn out by now..............sodeep

that would be a good start. pull the plug on # 1 cylinder and plug into wire now crank engine you should get spark same as # 5 cylinder if no spark replace the coil pack