How do i remove the fender panel to tighten the driver's side door hinge on a 1994 Ford F250? when I open the door the door drops down a bit, so I assume they're just loose and it's not an issue with the bushings, but I can't get at the hinges from just opening the door, I think the panel needs to be removed. I've never worked with body panels before, though. Can this just unbolt?

THIS IS A TWO PERSON JOB!!
Open the door wide for access. Get a look at each hinge and see if the bolt heads are accessible. If not it will involve stripping door trims and possibly front fenders.
If you can get to the hinge bolt heads, first remove the door check strap across the centre line of the door. This will allow you to swing the door a bit wider making access easier. Wind the window down a short distance as a handle. Then,
SUPPORT THE WEIGHT OF THE DOOR!
Slacken the LOWER hinge bolts leaving them in loosely to act as a brake if the door drops.
Start to remove the bolts in the upper hinge. Get your helper to support the door as it starts to swing loose. Take out the loose upper and lower bolts and remove the door.
To refit the new door, get your helper to hold it in position while you install the top bolt in BOTH hinges. Then install the lower bolt in each hinge. Tighten all bolts to the correct torque.
Lastly, refit the door check strap and close the door to check it lines up.

once you have removed the headlight assembly and remove the bolt behind the headlight assembly, continue locating the 10mm bolts attaching the fender along the top side, along the bottom in front and behind of the tire, open the drivers side front door, look into the opening between the door hinges and with a flashlight and a long extension on your ratchet you will then remove the two bolts between the fender and door, one on top and one at the bottom. you also have to remove the retaining bolts that attach the inner fender liner to the fender.

you have to mach it up its a maybe

you have to replace door hinge. Most often, you have to remove fender for access.

Should have kept going-it's just screws or bolts, but some are almost hidden-like front of fender and rear along door opening. Take off fender lining and look some more.
I sort of know what you mean-can be hard to get to the door hinges. have you tried like a universal joint in your ratchet and socket?

No. The door hinge bolts thread directly into the door frame. There are no nuts on the other side. Slap a socket on it and give it a crank.

go look at the passengers side. take note of the door seam and fender seam width. its about the width of a piece of cardboad. additionally look at the door hinges on the passenger side. it may or may not have washer shims. if they do/dont then just match up with passenger side. it takes 2 people to hang the door. screw in door hinges "finger tight" just to take off the weight of someone holding the door. play with the hinges until you can open/close door without binding or crimping fender at the seam. do not over tighten hinge bolts until the door opens/closes unobstructed. bottomline 2 people needed. slow and tedious job. you may have to add or take shims(washers) out for good fit. note that you may have to add shims to the inner door hinges or to the fender hinges where they meet. hope this is clear instructions.

remove door panel there is 1screws in the door handel pocket athend one at the top front corner once removed the panel will pull off there an a bunch of plastic push pins on the back side of panel work it off slowly to avoid breaking them unplug switches and set panel aside remove insulation sheet if there motor may be rivioted to regulator if so drill out riviots dont drill them out to big unplugg motor and remove be carfull that window doesnt drop down on you new motor sould bolt in make sure bolts dont interfere with window operation may have to put them in from the inside with nuts out to clear likage test and reassemble

You will need to remove the door panel to gain access to the handle. Roll the window up or down as needed to get to the nuts that attach the handle to the door. You will also need to remove a rod the goes to the door lock. You will see the rod after the door panel is removed. Good luck.