How do I replace the rear door handles on my nissan pathfinder 55 reg

Even the manual is vague here. You need to look under the chrome trim where the main hatch lever is. Off to the far right is a handle which, if you get down and look, appears to be a vent or something. Put your fingers in and pull up, this will release the hatch... then pull up on the small handle on the hatch itself.

Check on youtube for videos on it. You will have to remove the inner door panel-the hardest part-to get to it. Then take off the latch rods-unclip them and remove the two screws or bolts holding the old handle to the door frame, then as you remove it, work the latch rods out of their respective holes.

Check childproof lock if you can open it from the inside, but usually the connection between the handle and the lock for the outside door handle breaks.
if you can't open the door using either inside or outside door handles, go to a locksmith, auto electrician or a Nissan dealer or risk severely damaging the interior door panelling trying to do this yourself...
Please get back to us with the solution you found worked as it may help someone else in the future, thanks.

Is it REAR passenger door?
DO NOT overlook the small switch on the "CHILD PROOF" safety switch.

This can be your problem if it's only occur on the two rear doors.

its most likly not a door loock problem its probally a cable issue if the handel inside attaches via cable and its wrong best solution is to pop pannel off inside

Cut where the latch connects with a sawzall. Replace latch post whee the latch articulates.

2006 Nissan Pathfinder rear passanger doors don't open unless opened from insinde handle first. Then will open all the time until central locking is used then same problem occurs

I just replaced this on my 95. Past the hole in the door there should be a up-side down L shaped metal pole, but that pole can get lost inside the door and you have to search around with maybe a coat hanger to fish it into place. Once you find it grab it with a needle nose pliers and get the new handle at the same time, then pry and hook the L shape in to the eye-let of the new door handle. Once you have hooked the handle to the metal L pole, then you have 2 metal shoulder poles to slide into the hinging part of the new handle.

i started by removing ashtray and the screw underneath. it would be easier to remove rear seat as access is not so good to move around. wind window down, then carefully pull from top of trim, it should come away fairly easy. the trim is held on by push in clips but you need to careful as they break easy. behind the inside door handle is a plastic backing plate which i found easier to remove first. now the outside handle can be undone and i simply pulled the cable and the door opened. the cable was broken where it joins the handle so a new cable is needed.

Find the screws in the inside door handle, remove the handle and disconnect the relay rod(s).
Remove the screws under the armrest.
Starting at the lower outer (rear) corner, carefully pry the panell off popping each "clip" out of its socket while leaving each clip attached to the panell.
Then lift the panell up to release the upper most edge where it wraps over the top of the door body and presses the weathestrip against the glass.
Carefully disconnect any wiring atached to the panell.