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hi , if you are sure the no. 6 cylinder is misfire then change the ignition coil if you are sure but if you are going to buy a new coil better buy all 6 coils and it will last longer if not after no.6 then no.5 or 4,3, until you change all of it .....for rough runs pls flush / change ATF every 20,000 km and change engine oil every 5,000 km , change the exhaust (o2) sensor it make a lot of different , resetting your throttle sensor and speed sensor , all the above must change it with nissan oem part and it not that expensive too.
P0303--"Cylinder 3 Misfire Detected". The PCM detected a misfire on cylinder 3,most likely an ignition issue.If your engine has one coil per cylinder,see if you can swap the coils(don't forget to mark the suspect coil).You will have to clear the existing code(the PCM will usually disable the fuel injector on the dead cylinder).See if a different code now sets(P0301 is cyl 1,p0302 is cyl 2,etc).If the code is the same,you will want to look at the plug(and wire,if your engine has plug wires).You could swap the wire and plug (one at a time) to see if the code changes with any of these.Of course,this is easier if you have your own code sanner(you can get a basic one for under 50 bucks-that's all I have,and it gets the job done!) If none of the parts swapping finds the solution,you can do similar swaps on the fuel injectors,but it is a little more work than the ignition stuff.
most likley a ignition coil is failing, is unfortunatly common for the A33 maxima. these engine have 6 coils, one for each cylinder. the only way to work out which of the 6 is the faulty one is to remove the little cover over the front bank of spark plugs, has 4 allen key bolts, then you can see the front 3 coils and the rear 3 are inbetween the manifold pipes. each coil wiring will have a button/leaver on the connectors (i think they are green) and if you push this in will release connector.
when the engine is missfireing unplug one coil at a time then reconnect after. if the engine runs worse that coil is working. if you unplug 1 that makes no change, that is the the one thats not working. replace the coil and the spark plug.
do not worrry, there is only 12volts at these connectors, not spark plug voltage
The ignition coils are listed from 'A" to "L" (up to 12 cylinders) and they are in sequence according to the firing order. This diagram will help you out, and according to this diagram for your vehicle, "E" is the fifth letter so the fifth cylinder in the firing order is cylinder #6, and as you can see from the diagram that coil "E" or cylinder #6 is the second spark plug or cylinder from the front on the drivers side of the engine.
2000 maxima are famous for having bad coils - those cost about $350 if you dealer isn't trying to rip you off (otherwise they will charge $600). I also read you can get an aftermarket coil at Autozone.
check plug wire coil if that dosent do it pressure test cylinder make sure its ok. if pressure goes down bad cylinder or piston or it could be the head. i hope this was usefull. write me back let me know how it went