The truck has a horrible sound coming from the top of the motor, it is very loud and when driving between 45 and 55 feels like a jerking motion back and fourth any ideas what the problem could be chevy 2000 s10 has a new transmission and radiator also the fuel like had a leak and that was fixed too. could it be injectors?

It sounds like a misfire, My suggestion is that you change the spark plugs and wires first. Then if it continues look for a vaccum hose that has come detached.
Owner of a 2003 Ford Ranger.

The first thing you do is to have the fault codes checked with a scan tool.

loud idling may be higher rpm's and unresponsive brakes point to a vacuum leak in the power booster hose that will run very clos to the reservoir.

Sounds like a regular cylinder miss.
Is the check engine light on ?
Its also possible you have a pulley or something out of balance.

It sounds like you may have a wheel bearing/ hub assembly starting to go bad...You can check this by jacking up the front end and checking for slight play in each wheel when you try to move tire in a side to side,and up and down motion basically But you just want to use a wiggle motion...you should be able to feel a bit of excessive play in the side which is going bad...One side will be tight with no play,and the other will have some play if the wheel bearing hub assembly is going bad...

It sounds as if the wiper linkage has come adrift, normally will require renewal of a link arm

I'm not sure about the noise, but the jerking motion might be because your the center roller (located in the rear middle of the sliding door) has worn out and need to be replace. This is a will known problem.

Your problem is very hard to answer because 05-10 odyssey has so many problem with sliding door.

rear latch:
-door not to latch close
-door not to work

front latch:
-door not to open

lock actuator:
-door not to open
-door will pop when opening

window motor:
-window not to work
-door will only open half way

center roller:
-jerking motion when opening
-door kick back close while opening
-door kick back open while closing

Door motor:
-door not to work
-cause door to jam

good luck

could very well be but without a drive i cannot really say sorry but some things i have to trust the local mechanic as i cannot see or hear it over the internet

sounds like you may have coolant in your motor

check for a strut mount worn or defective also the front strutt traction bar,see also how the motor and trasmission mount are.