For the past day, intermittently when I hit the brakes, it sounds like Im driving over a rumble strip found on the highways. It happens in the front, as far as I can tell, and its fairly loud. Ive looked around the wheels and see nothing rubbing. I have no clue what can be causing this, its in 2wd, and still goes into 4wd with out issue. 84k miles.

It may be a sticking brake caliper, worn brake pads or shoes. Probably needs a brake job. Take it for a ride on the highway and try not to use your brakea as much. If its still hot then its ba wheel bearings that is causing the heat. The bad wheel bearings will produce a low rumble sound when driving.

Sounds like a half shaft. Reach around behind each wheel and see if there is play in the shaft that leads from the wheel to the transmission. There should be no play. Other possibility is a bearing hub. Jack up car, grab the tire at 9 and 3 o'clock. Shake wheel if there is movement not from the tie rod then it is the bearing hub.

If you feel it in the brake pedal and/or steering wheel you have a bad brake pulsation in the front brakes. Just replace the rotors as having them turned or machined will make them warp sooner due to the loss of material from machining. More cost effective to just replace them. If this vehicle has a 4 speed automatic......shift down into D to hook-up to the engine thru the transmission to help slow the vehicle down long hills like mountain driving. GET IT OUT OF OVERDRIVE TO SAVE THE BRAKES.
Hope this solves your problem.

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look for play or binding in the universal joints

What would a "rumble strip" sound like? Squeaking, metal clanking against metal? Trailblazers have lots of noises that are a nuisance, and I've fixed most of them.

Do you have the problem when you turn on the car as well? I had this same problem, turns out the alternator was going bad. A few months later the alternator went. After the alternator was replaced, the problem went away.

That noise sounds to me like a Ball Joint problem. I would check to see if you have fittings to grease the front suspention.

Good luck, Allen

If it is only when you push on the gas,check your cable,to make sure not rubing on somthing if ok check pipes under car and all cuplings to muffler.

you have a bad torque converter. well documented on the Honda Pilot forum and Honda is ripping everyone off including me on the problem.

engine monts need to be replaced