My dodge hemi 5.7 keeps coding multiple misfires I replaced the plugs,wires,coil packs,two map senors used injector cleaner. When you stop then it gets tough if I put it in park or neutral great.

neither if if ran fine for a few days after your repairs
misfires are more likely from problem injectors, low fuel pressures or injector wiring problems
use a couple of vans of quality injector cleaner first

If you had code P0305, I don't know why they would have done anything to the #2 cylinder but if they have already replaced the plugs, wires and injector; here are a few more items to check:
1) Check connections from ECM. Look for any corrosions or bent/broken pins.
2) Check the fuel line pressure
3) Check the engine compression
4) And if the above are good, then you will probably have a defective ECM

No a knock sensor can not make a misfire. Check the coils, plugs and fuel pressure .The random misfires are cause the knock sensor to throw the code.

Could be bad coil,bad wires,

Make sure plugs are gapped correctly and coil pack is good . If can't feel it missing could be a false code generated by computer . Hope this helps

Hi Jason:
A Random/Multiple Cylinder Misfire Detected unfortunately doesn't tell you specifically which cylinder(s) is/are mis-firing, nor why.

A code Random/Multiple Cylinder Misfire Detected may mean that one or more of the following has happened:
Faulty spark plugs or wires
Faulty coil (pack)
Faulty oxygen sensor(s)
Faulty fuel injector(s)
Burned exhaust valve
Faulty catalytic converter(s)
Stuck/blocked EGR valve / passages
Faulty camshaft position sensor
Defective computer

Possible Solutions:
If there are no symptoms, the simplest thing to do is to reset the code and see if it comes back.

If there are symptoms such as the engine is stumbling or hesitating, check all wiring and connectors that lead to the cylinders (i.e. spark plugs). Depending on how long the ignition components have been in the car, it may be a good idea to replace them as part of your regular maintenance schedule. I would suggest spark plugs, spark plug wires, distributor cap, and rotor (if applicable). Otherwise, check the coils (a.k.a. coil packs). In some cases, the catalytic converter has gone bad. If you smell rotten eggs in the exhaust, your cat converter needs to be replaced. I've also heard in other cases the problems were faulty fuel injectors.

Random misfires that jump around from one cylinder to another (read: P030x codes) also will set a P0300 code. The underlying cause is often a lean fuel condition, which may be due to a vacuum leak in the intake manifold or unmetered air getting past the airflow sensor, or an EGR valve that is stuck open.

Hope this helps; also keep in mind that your feedback is important and I`ll appreciate your time and consideration if you leave some testimonial comment about this answer.

Thank you for using FixYa, have a nice day.

its a possibility that the # 1 fuel injector is plugged or is not working right. run some good injector cleaner in it and see if that helps. if not check the injector, for it may be bad. good-day !

P0300 Random/Multiple Cylinder Misfire Detected this is the code your refering to what it means is it means your haveing a misfire in your fireing system it dosent mean that it has to be a plug could be a plug wire or a coil pack on the plug is causeing this or a faulty fuel injector replace your plug wires if it goes off if not test your injectors its in one of theses good luck

A multi misfire may mean that one or more of the following has happened:
Faulty spark plug or wires, Faulty coil (pack), Faulty oxygen sensor(s), Faulty fuel injector(s), Stuck/blocked EGR valve / passages, Faulty camshaft position sensor, Defective computer.

The engine is stumbling or hesitating, check all wiring and connectors that lead to the cylinders (i.e. spark plugs). Depending on how long the ignition components have been in the car, it may be a good idea to replace them as part of your regular maintenance schedule. I would suggest spark plugs, spark plug wire, distributor cap, and rotor (if applicable). Otherwise, check the coils (a.k.a. coil packs). In some cases, the the problems were faulty fuel injectors. 

Random misfires that jump around from one cylinder to another (read: P030x codes) also will set a P0300 code. The underlying cause is often a lean fuel condition, which may be due to a vacuum leak in the intake manifold or unmetered air getting past the airflow sensor, or an EGR valve that is stuck open.

Good luck and hope this information helps, keep me posted, be glad to help you get the truck running 100% again. Not sure if your running a K&N air filter, and if you are there may be a flim of oil on the MAF sensor that is making you run lean. You may want to spray down the MAF sensor with a can of MAF cleaner. 

i have a 2001 chevy z-71 5.3L. I keep getting a random/multiple misfire code for cylinder 1 . I have replaced plugs, wires, coil pack(only on #1 cylinder)., and fuel pump. I still keep getting the cylinder 1 misfire code. I put truck on a scanner and watched the cylinders. # 1 misfires at idle but quickly stops misfiring at around 1000 rpms. you can here the engine miss at idle but truck runs great on road . anyone else ever had this problem?