Question about 2006 Toyota Sienna

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Error P0300 random/multiple cylinder misfire detected

I just bought a 2003 Toyota Camry and I needed to drive 2 1/2 hours to get home and I was anxious because I had to work, so I didn't check the fluids (I know that was stupid). I drove all the way home and when I got home the temp was in the red. I waited till the morning and checked the water. It was completely empty. After that, the motor misfired and the check engine light stayed on. I hooked up a meter and found the error code P0300 and Cylinders 2 and 4 are misfiring. What does this mean? What do I have to change? I was forced to by a car because I just totalled my last car a couple weeks ago. I would appreciate all the help I can get... Thank you!

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  • k_luv_in_haw Jun 24, 2009

    Thank you I will try that! I tried running the car again and it still over heats, so I think that the head gasket IS bad. I have such bad luck with cars. Thanks again!

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  • 72 Answers

Because of the way it is set up with the coils, if one cylinder misfires it affects another one. Also, if a plug or plug wire is bad it will do the same thing. But it is possible that the head gasket is bad because you said it was low on coolant. That will also cause a misfire. Check plugs to see if any of them are wet.

Posted on Jun 23, 2009

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SOURCE: 2000 CIVIC System too lean Cylinder 3 and 4 misfire Deteced

  1. P0171: This means that the oxygen sensor has detected a lean air-fuel ratio. This can be caused due to a vaccuum leak or a problem in the HO2S circuit or the HO2S (Heated Oxygen Sensor) itself. (Bank one Sensor one). This is commonly located along the exhaust pipe. It could also be a bad Mass Air Flow sensor or a bad Engine Coolant Temperature sensor. Diagnostic checks will be needed to be carried out to be verified though
  2. Well as for the other codes, it means #3&4 cylinders are misfiring. It is a possibility that the P0171 code mite have caused the others to show up. I can be wrong though. But it is a strong possibility. If the air fuel mixtue is too lean indeed, mis-firing will occur, unless it is an actual electronic and not a mechnical problem. By the way, when these codes appear, how is the engine's performance. Does it remain the same or behaves poorly?

Posted on Feb 14, 2009

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SOURCE: 96 bmw 740il misfire

This is a pretty common problem. I would change your valve cover gaskets. They run around ~ 50 bucks. If they are bad it will leak oil into spark plug well and cause a misfire. Very known on the 740.. Also if tune was not anytime not too long ago id change spark plugs while you at it. Then clear the computer and if you still get misfire on 8 try changing the ignition coil which is right about the cylinder with cylinder ignition coil 5. clear the computer. if you get random misfire and misfire cyclinder 5 after then its your ignition coil. parts store runs around 100 bucks

Posted on May 04, 2009

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SOURCE: setting code P0300- random multiple

This could be any number of problems in your spark system but most likely your control module for your spark plug coils.

Posted on Aug 22, 2009

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SOURCE: 2006 RAV4 V6 multiple cylinder misfire, VSC, check engine and sli

You need a scanner to pull out the engine light codes.
Use a shopu manual to aid you with the diagnosis and repair.
The slip indicator and vsc light being on means these systems are not working. Once you pull the codes and do the repair and erase the codes the lights will go off.
There will be a code in there for the misfiring.
Good luck and keep me posted.

Posted on Mar 09, 2010

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