Code P0300 I am having the same problem. I have a 1999 Chevy Tahoe. We have replaced the following: Plugs Wires Cap & Rotor PCV Valve TPS Sensor Catalytic Converter Upper & Lower Exhaust manifolds Oxygen Sensors - all three Used Lucas Fuel Treatment - regularly Transmission I'm completely at a loss and I dont have any more money to guess. PLEASE HELP!!!

Code 123 is for a problem with the throttle position sensor circuit. So if you have replaced the sensor, either it is not calibrated or there is something going on with the wiring back to the computer.
Code 443 is for the EVAP purge control circuit. Same thing if you have replaced the purge solenoid.
You could also have a problem with the engine computer. You'll need a shop manual to get the testing procedures for each code.

Here's a link to the P0300 code,

Check for vacuum leaks. See tips at first link below.
There is a test for the tps at the second link.
Do It Yourself


Repair Guides Fuel Injected Electronic Engine Controls Throttle Position...

usually this code is followed by another number 1-4 or 1-6 or 1-8 depending on how many cylinders your vehicle has ,, what the code you got is a basic P0300 Random/Multiple Cylinder Misfire Detected A code P0300 may mean that one or more of the following has happened:

• Faulty spark plugs or wires
• Faulty coil (pack)
• Faulty oxygen sensor(s)
• Faulty fuel injector(s)
• Burned exhaust valve
• Faulty catalytic converter(s)
• Stuck/blocked EGR valve / passages
• Faulty camshaft position sensor
• Defective computer
• I would suggest spark plugs, spark plug wires, distributor cap, and rotor (if applicable). Otherwise, check the coils (a.k.a. coil packs). In some cases, the catalytic converter has gone bad. If you smell rotten eggs in the exhaust, your cat converter needs to be replaced. I've also heard in other cases the problems were faulty fuel injectors.
  Random misfires that jump around from one cylinder to another (read: P030x codes) also will set a P0300 code. The underlying cause is often a lean fuel condition, which may be due to a vacuum leak in the intake manifold or unmetered air getting past the airflow sensor, or an EGR valve that is stuck ope
  

P0300 Diagnostic Code - Random/Multiple Cylinder Misfire Detected
Basically this means that the the car's computer has detected that not all of the engine's cylinders are firing properly.

A P0300 diagnostic code indicates a random or multiple misfire. If the last digit is a number other than zero, it corresponds to the cylinder number that is misfiring. A P0302 code, for example, would tell you cylinder number two is misfiring. Unfortunately, a P0300 doesn't tell you specifically which cylinder(s) is/are mis-firing, nor why.

Symptoms may include:
* the engine may be harder to start
* the engine may stumble / stumble, and/or hesitate
* other symptoms may also be present


Causes: A code P0300 may mean that one or more of the following has happened:
* Faulty spark plugs or wires
* Faulty coil (pack)
* Faulty oxygen sensor(s)
* Faulty fuel injector(s)
* Burned exhaust valve
* Faulty catalytic converter(s)
* Stuck/blocked EGR valve / passages
* Faulty camshaft position sensor
* Defective computer

Possible Solutions:
* If there are no symptoms, the simplest thing to do is to reset the code and see if it comes back.

* If there are symptoms such as the engine is stumbling or hesitating, check all wiring and connectors that lead to the cylinders (i.e. spark plugs). Depending on how long the ignition components have been in the car, it may be a good idea to replace them as part of your regular maintenance schedule. I would suggest spark plugs, spark plug wires, distributor cap, and rotor (if applicable). Otherwise, check the coils (a.k.a. coil packs). In some cases, the catalytic converter has gone bad. If you smell rotten eggs in the exhaust, your cat converter needs to be replaced. I've also heard in other cases the problems were faulty fuel injectors.

Random misfires that jump around from one cylinder to another (read: P030x codes) also will set a P0300 code. The underlying cause is often a lean fuel condition, which may be due to a vacuum leak in the intake manifold or unmetered air getting past the airflow sensor, or an EGR valve that is stuck open.


Test it and keep us updated.

P0300 Diagnostic Code - Random Misfire
Technical description:--
Random/Multiple Cylinder Misfire Detected:---
Exactly what does this code means:--
Basically this means that the the car's computer has detected that not all of the engine's cylinders are firing properly.
A P0300 diagnostic code indicates a random or multiple misfire. If the last digit is a number other than zero, it corresponds to the cylinder number that is misfiring. A P0302 code, for example, would tell you cylinder number two is misfiring. Unfortunately, a P0300 doesn't tell you specifically which cylinder(s) is/are mis-firing, nor why.
Symptoms:--
the engine may be harder to start.the engine may stumble / stumble, and/or hesitate.
other symptoms may also be present…There may be rough idle, sputters and stallsand jerks.
Causes:--
A code P0300 may mean that one or more of the following has happened:
Faulty spark plugs or wires, Faulty coil (pack), Faulty oxygen sensor(s)
Faulty fuel injector(s),Burned exhaust valve, Faulty catalytic converter(s)
Stuck/blocked EGR valve / passages, Faulty camshaft position sensor, Defective computer.
Possible solutions for this error problem:--
If there are no symptoms, the simplest thing to do is to reset the code and see if it comes back.
If there are symptoms such as the engine is stumbling or hesitating, check all wiring and connectors that lead to the cylinders (i.e. spark plugs). Depending on how long the ignition components have been in the vehicle, it may be a good idea to replace them as part of your regular maintenance schedule. I would suggest spark plugs, spark plug wires, distributor cap, and rotor (if applicable). Otherwise, check the coils (a.k.a. coil packs). In some cases, the catalytic converter has gone bad. If you smell rotten eggs in the exhaust, your cat converter needs to be replaced. I've also heard in other cases the problems were faulty fuel injectors.
Random misfires that jump around from one cylinder to another (read: P030x codes) also will set a P0300 code. The underlying cause is often a lean fuel condition, which may be due to a vacuum leak in the intake manifold or un-metered air getting past the airflow sensor, or an EGR valve that is stuck open.

A code P0122 may mean that one or more of the following has happened:

• TPS not mounted securely
• TPS circuit short to ground or another wire
• Faulty TPS
• Damaged computer (PCM)

Possible Solutions Some recommended troubleshooting and repair steps are:

• Carefully check the throttle position sensor (TPS), wiring connector, and wiring for breaks, etc. Repair or replace as necessary
• Check the voltage at the TPS (refer to a service manual for your vehicle for specific information). If the voltage is too low that is indicative of a problem. Replace if necessary.
• If recently replaced the TPS may need to be adjusted. On some vehicles the installation instructions call for the TPS to be properly aligned or adjusted, consult a repair manual for specifics.
• If there are no symptoms at all, the problem may be intermittent and clearing the code may resolve the issue temporarily. If this is the case then you should definitely check the wiring to be sure it's not rubbing on anything, grounding, etc. The code may come back.

A code P0300 may mean that one or more of the following has happened:

• Faulty spark plugs or wires
• Faulty coil (pack)
• Faulty oxygen sensor(s)
• Faulty fuel injector(s)
• Burned exhaust valve
• Faulty catalytic converter(s)
• Stuck/blocked EGR valve / passages
• Faulty camshaft position sensor
• Defective computer

Possible Solutions If there are no symptoms, the simplest thing to do is to reset the code and see if it comes back.
If there are symptoms such as the engine is stumbling or hesitating, check all wiring and connectors that lead to the cylinders (i.e. spark plugs). Depending on how long the ignition components have been in the car, it may be a good idea to replace them as part of your regular maintenance schedule. I would suggest spark plugs, spark plug wires, distributor cap, and rotor (if applicable). Otherwise, check the coils (a.k.a. coil packs). In some cases, the catalytic converter has gone bad. If you smell rotten eggs in the exhaust, your cat converter needs to be replaced. I've also heard in other cases the problems were faulty fuel injectors.
Random misfires that jump around from one cylinder to another (read: P030x codes) also will set a P0300 code. The underlying cause is often a lean fuel condition, which may be due to a vacuum leak
in the intake manifold or unmetered air getting past the airflow sensor, or an EGR valve that is stuck open.

have you checked the tps sensor?

Hi,

A quick Internet search on those codes pulled up the following info.
http://www.obd-codes.com/p0440

• Remove and reinstall the gas cap, clear the code, and drive for a day and see if the codes come back.
• Inspect the EVAP system for cuts/holes in tubes/hoses
• Inspect for damaged or disconnected hoses around the Evap purge solenoid
• Check and/or replace the sensor
• Check and/or replace the purge valve
• Have a professional use a smoke machine to detect leaks

http://www.obd-codes.com/p0300

• Faulty spark plugs or wires
• Faulty coil (pack)
• Faulty oxygen sensor(s)
• Faulty fuel injector(s)
• Burned exhaust valve
• Faulty catalytic converter(s)
• Stuck/blocked EGR valve / passages
• Faulty camshaft position sensor
• Defective computer