Runs poorly 150 compression all cylinders runs poorly, miss fire ,code cam shaft sensor, several other codes oxgyen sensor,

If your 96 E250 300ci was running perfectly and then started missing and the code is indicating a miss fire in cylinders 1 and 2, there could be a few potential causes. Here are a few steps you can try to troubleshoot and resolve the issue:

1. Check the ignition system: Make sure that the ignition system is functioning properly. Check the distributor cap, rotor, spark plug wires, and ignition coil for any signs of wear or damage.
2. Check the fuel system: Make sure that the fuel system is functioning properly. Check the fuel filter, fuel pressure, and fuel injectors for any signs of wear or damage.
3. Check the compression: A compression test can help to determine if the engine is getting enough compression to run properly. Low compression in cylinders 1 and 2 can cause the engine to miss fire.
4. Check the vacuum lines: Make sure that the vacuum lines are properly connected and not leaking. Any vacuum leaks can cause the engine to run poorly and miss fire.
5. Check the PCV valve: The PCV (positive crankcase ventilation) valve can become clogged or malfunctioning and cause the engine to run poorly and miss fire.
6. Check the EGR valve: The EGR (exhaust gas recirculation) valve can become clogged or malfunctioning and cause the engine to run poorly and miss fire.
7. Check the Engine Control Module: The Engine Control Module (ECM) controls the ignition and fuel systems and if it's malfunctioning it can cause the engine to miss fire.

It's important to note that some of these steps may require special tools and knowledge of the vehicle's engine system, so it's best to take it to a professional mechanic to avoid causing more damage.

DTC P0340 will set if the PCM voltage on cylinder #4 signal wire is not pulled to ground (cam signal pulse) when:
Diagnostic Aids
Important: A cam pulse missing may not affect engine operation.
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An open or high resistance on the #1 plug wire or plug will result in DTC P0340 setting.

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Inspect the EIS towers and plug the wire connections for corrosion or other signs of poor retention at connections.

The electronic ignition (EI) module supplies a signal to the PCM whenever it determines that the #4 cylinder fired on its compression stroke. Because of opposite coil tower polarity, the simultaneous fir of #1 and #4 cylinders are of opposite polarity as well. Under most conditions, except decel, the waste spark cylinder fires before the compression cylinder in sequence. The EI module can determine this polarity sequence and voltage amplitude by using capacitive pickup plates located under the 1/4 coil. If the module senses a positive to negative sequence and high negative spike when #4 is on TDC, it pulls the PCM cam signal to ground signaling that #4 has just fired on compression. This signal along with the double pulse received from the CKP sensor, synchronizes spark and fuel timing.
Beside plugs , plug wires need to be replaced as well !

replace the injector in no 2 cylinder

This P0341 code basically means that the powertrain control module (PCM) detected a problem with the camshaft signal. The camshaft position sensor (CPS) sends a specific signal to the PCM for Top Dead Center on the compression stroke as well as signals indicating the position of the cam sensor. This is accomplished through a reluctor wheel attached to the camshaft that passes by the cam sensor. Any time that the signal to the PCM is inconsistent with what the signal should be, this code is set. NOTE: this code can also be set by extended cranking periods.
FB.init("dd7d9e9681341cde77587bc6a2029f6f"); OBD-Codes.com on Facebook Symptoms The car will likely run with this code set, as it is often intermittent and also because the PCM can often operate the vehicle in "limp-in/limp-home" mode even with a cam sensor signal problem. There may be no noticeable symptoms other than:

• Poor fuel economy (if engine runs)
• Possible no start condition

Causes A code P0341 may mean that one or more of the following has happened:

• Cam sensor wiring routed too close to spark plug wiring (causing interference)
• Poor wiring connection at cam sensor
• Poor wiring connection at PCM
• Bad cam sensor
• Damaged reluctor wheel

Possible Solutions Often relacing the sensor fixes this code, but not necessarily. Therefore it's important to check the following:

• Check that the wiring isn't routed too close to any secondary ignition components (coil, spark plug wires, etc.)
• Visually inspect the wiring at the sensor for any burn marks, discoloration indicative of melting or chafing
• Visually inspect the cam sensor for damage
• Visually inspect the reluctor wheel through the cam sensor port (if possible) for any missing teeth or any damage
• If reluctor isn't visible from outside the engine, visual test can only be done by removing cam shaft or intake manifold (depending on engine design)
• If all checks out okay, then replace the sensor.

Related Camshaft Trouble Codes: P0340

Try moving the coil pack from cylinder 1 to another cylinder (swap locations) and see if the same code comes up. If code is different, then coil pack is bad. Other reasons for miss; bad injector, poor compression.
Also, I know you changed plugs already, but always use AC Delco 43-103 plugs on this vehicle.

compression piston #2 , loan a compression kit from AutoZone and test the compression , if it is under 150 PSI ? you have bad piston rings .
knock sensors sense any play in engine from crank shaft bearings all the way up to piston pins , all have bushings and rods have bearings ,
the other cause is the distributor may not be adjusted properly to time the firing sequence for the plugs in relation to fuel ratio/air mix , the 200 model is mechanical one , and the firing sequence is very important to align exactly with crank timing .
is the smoke dark or white ? if dark ? distributor need correction if white ? piston ring problem .

The coil pack is most likely the problem for the miss fire on the cylinder,but the engine most of the time will still run,just poorly.Crank shaft sensor would be the next thing to check,if there is fuel pressure present at the fuel rail.Also enough fuel pressure.

Coil pack fault on cylinder number 4

Have you tried replacing the throttle positioning sensor?

which two cylinders?