Random misfire on first start gets worse w/ low gas

How To Fix P0300 random misfire codes in your car ...

? 2:56
https://www.youtube.com/watch?v=OyvdWeyDHf4
Feb 5, 2010 - Uploaded by Scotty Kilmer
Scotty Kilmer, mechanic for the last 46 years and counting, shows how to fix your car if the check engine light ...

P0300 - OBD-II Trouble Code - RepairPal

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OBD II Fault Code. OBD II P0300. Fault Code Definition. Random, Multiple MisfireDetected. Symptoms. Check Engine Light flashing; Rough running, hesitation ...

P0300 - Check Engine Light Diagnostic Trouble Code ...

https://www.engine-light-help.com/P0300-check-engine-light.html

The misfire detection monitor, a software strategy built into the computer, is designed to detect an engine misfire. The computer can also normally identify the ...

Random-Misfire Page

www.random-misfire.com/

misfires are more from faulty injectors / leaking injectors so check the codes as the misfire code will indicate the problem cylinder
exampl code p0300 is random misfires and codes p0301 through to p 0308 is the cylinder ie p 0303 is no 3 cylinder

Error Code: P0300
Description:
Random/Multiple Cylinder(s) - Misfire Detected
Problem Area:
Air Intake System leaking.
Fuel Supply faulty.
Injector(s) faulty.
Ignition Cable(s) and/or Spark Plug(s) faulty.
Ignition coil(s).Exhaust Gas Recirculation (EGR) Valve stuck/open.
Camshaft Position Sensor faulty.
Low compression.
Wiring.

Solutions:
Check Misfire Recognition.
Check Air Intake System.
Check Fuel Supply.
Check Injector(s) and Injector Sealing.
Check Ignition Cable(s) and Spark Plug(s).
Check Ignition Coil(s).
Check Exhaust Gas Recirculation (EGR) Valve .
Check Camshaft Position Sensor.

Possible an injector leaking down, saturating cylinder and spark plug., causing a misfire on startup and clearing up after it runs for a while.

plugs might need cleaning

indicates a low fuel pressure problem
random misfires are predominately fuel pressure related rather the electronic
check pump operation , pressure regulator, filter , and EVAP for not venting the fuel tanl

First look at fuel pressure pump jam

what type/size of engine? what year model truck? several things to check for a random misfire. also , how many miles on the truck? coils are a possibility but they usually set specific cylinder misfires if it is equipped with coil on plug ignition system. a vacuum leak or low fuel pressure can cause a random misfire. also broken valve spring can cause the misfire because it effects the engine vacuum.

This sounds like a classic GM plugged catalytic converter symptom. If you like you could remove the oxygen sensor in front of the cat and try driving it. With the sensor removed, the exhaust can escape a little more easily and will drive better if the cat is the problem. If you have the right fitting and a gauge, you could actually measure the back pressure at the oxygen sensor hole. It should not be any higher than about 2 psi at 3000 rpm. I have seen this problem several times now on these vans and I'm almost certain this is your problem.
Hope this helps,
Dave

http://sun-transport.com/Automotive-Repair-Tools/Exhaust-Back-Pressure-Tester/

AmyLynn001, 1st thing, let the car sit for a couple hours (because u smell gas, it's definitely flooded). Turn the key to start (do NOT touch the gas pedal!! Cars are designed now to start w/out touching the gas pedal. If u do, u will flood it, and make it even more difficult to start) When u turn the key, only hold it to turn the engine over for no more than 10 seconds. If after the 10 seconds it doesn't start, turn key off, wait about 10 seconds, repeat. (this is to reduce wear and tear on the starter, and to not run the battery down real quick). It sounds like several problems coming together caused this. U state that the car needs a tune up, it's likely the overheating, need of a tune up (car not performing to optimum efficiency) and pushing on the gas pedal, resulting in flooding, all came together to create this no start condition. Eliminate any one (preferably all!) and u should be able to start the car. So, hopefully just letting it sit and not touching the gas pedal while attempting to start will be enough to get u back on the road, then get that tune up soon. Let me know how u make out.