2000 cadillac dts. Vehicle is engine is skipping ane fuel needle pegs out to (E) empty while driving.

Sounds like at least one or more of the electrical wires leading to your fuel pump may be shorting out. Possibly corrosion or a weak point. If it is happening intermittently, the connection is probably on the verge of breaking, at which point your vehicle will stall and you will not be able to restart it. You will think that you have run out of gas because your fuel indicater will of course be buried in Empty, even if you have just filled the tank. In an attempt to locate a weak link in the electrical wires, start at the gas tank and trace the wires from there back to the engine. The wires are likely housed loosely in a plastic tubing that protects them under the vehicle and the corrosion point is usually near the end of the plastic tubing just short of where they connect at the plug at the fuel tank. If you find a weak link, you can slide the protective cover back, cut the weak part of the wire out, splice it back together. However, once you have cut one or more of the wires to the fuel pump, your vehicle's "computer" may have to be reset in order for it to even turn over because some vehicles have that default safety feature programmed into their "brain". (not a gadget the average DIY mechanic has in their tool box). There is very possibly a way to interupt the signal to the "brain" while splicing the wires, so that the "brain" is unaware that the wires were cut. Maybe disconnecting the battery, but of this I do not know. I don't think that temporarily pulling the (larger) fuse to the fuel pump would do the trick, because I think some computers have to be reset if that fuse has been pulled also. Good luck. Hope it is as simple as some accessible, easily repairable wires!