2003 6.0 F-250 ran out of fuel and won't start.

Ran out of gas and What?

Won't start?

Could have ruined an already worn fuel pump

Turn key on/engine off should hear pump run
for 3 or 4 seconds

Check fuel pressure if it runs with a gauge on
injector fuel rail or with a professional scan tool
data.

Try spraying the throttle body to see if it will run

Try disconnecting the battery AFTER you check for
codes,stored data, etc & write down what you get

Check spark plugs, leads, distributor cap & rotor arm, fuel pump, fuel filter, coil pack(s), relays, replace any items that are suspect IE Fuel filter which has probably not been changed since new even though they should be changed on all vehicles every 18 months, all of this can be done at home & will save you a lot of bucks in mechanic/garage fees,

fuel pick-up in tank is blocked it has a sock over the end as a gross filter to keep out any big junk from getting sucked into the pump and causing damage to it. the sock can get so plugged up that no fuel will flow, causing the pump to run for a short time then with no fuel flow to cool it it trips the safety and shuts off

Most Fords have a fuel reset button. When you ran out of gas you tripped the circuit. Most of the time the button will be on the passenger side by the kick panel. The exact location should be in your owners manual or your local library or auto parts store will have a copy of one for your specific vehicle.

If it is a 3.8 engine change the crank sensor,they go bad on the 3.8 engines.

@ items of concern spark or fuel. For spark as you crank the engine ,assuming that you have a tach on the dash.Does the tach show movement(this will be very small) if it does you have a fuel problem if it doesnt then you will need a crank position sensor

First try and change the fuel filter. this also happened on a van i worked on. I cahnged the filter and it runs fine now.

I am assuming you gave the fuel pump sufficient time to refill the fuel lines and pressurize the system before coming to the conclusion that it won't start. That said, you could try the fuel filter, but it is most likely going to be the fuel pump itself, especially if it is the original pump from the vehicle. Fuel pumps reside in the fuel tank and are cooled by the gasoline that surrounds it. If you are one who is always running low on fuel or just putting a gallon or two in it to keep going, you are accellerating the death of the fuel pump. I have seen many instances in the MOPAR minivans where a fresh fillup after a low fuel/run out of gas episode finished off an older fuel pump.

you probably have air in the lines, if you have a carb, spray some quick start into the carb and turn it over, if it starts and then dies when the starting fluid has run out, you probably need a fuel pump, since the running of the car should have blown out any air that was in the line, If your car is fuel injected, loosen the bolt cap at the end of the injector line that supplies the fuel,, and tap the key once,, ( don't start it,, ) just turn the key on and off 3 or 4 times, this should blow fuel out of that loose bolt head, if it does your getting fuel, if not, back to the fuel pump, also you can check this link, http://www.aa1car.com/library/us1296.htm

After for setting for so long it is possible the pump picked something up and it clogged the injector.