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im not sure if a 2000 f150 and a 2000 f250 have the exact steering column,but incase it is then check at the base of the column inside and you may see a triangler shape bracket that the shift cable connects to,there will be 2 torque screws holding the bracket to the column,either a t-20 or t-25 not sure,they may be loose so the shifter will be sloppy...my 2000 f150 had that problem and i stumbled upon it,it seems to be a 2000 year issue...about the manual hubs,try locking them in and drive forward and reverse very slow a few times,if they lock in then they are sticky and it takes time for the spring inside to push then together.lock the hubs in first,then after a while shift to 4x4,because if they are just sticky,it may strip the teeth on the lockouts from the axel turning against the inside of the lockout.
Check your vacuum pump located on the right side fenderwell. see if its running. Check the vacuum hose at the hubs for leaks or damage. repair if damaged. check for other vacuum leaks such as the grey hose going to the heater control valve.
The autolocking hubs are vacuum actuated. If they don't lock then you most likely have a vacuum leak somewhere. This usually occurs where the vacuum line (black rubber hose) attaches to the knuckle on the inside of each front wheel. These hoses get dry and crack. Another simptom of this leak is the AC changing from front vents to defrost vents when you switch to 4x4 so check for this. You could also have a vacuum leak in the hub diaphragm or one of the orings in the hub could be cracked or broken. If you cannot find a vacuum leak then the vacuum solonoid valve may be bad.
hub locks are worn out, especially if you cant turn them. And its not high and low. Its either auto?lock for switch style shift, or free /lock for old style floor shift. also hub seals could be worn or vacuum system not working.
There is an electrical vacuum pump on the pass fender well area under the hood. It will have a 2 wire connector, and you will see where a vacuum line hooks to it. First check the fuse #27 15amp lower left side of dash make sure its not blown. If blown change it out and see if works, if it blows again then you will need a new vacuum pump. Also the vacuum hub seals are known to leak and they can be quite expensive to have replaced. If you get the pump working and the dash working you can buy a hand held vacuum pump to check them.
Most likely vacuum problem. Does the A/C blow out of the correct location? i.e if you have it set to vent does it blow out of the vents? If not, then you have a vacuum leak somewhere. The vacuum lines to the autolock hubs is a common problem.