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Does it tick with just the ignition on but engine not running? if yes its a relay or solenoid trying to kick in. if only with engine running and its a deisel could be the injector relays. identify where the sound is coming from. if petrol could be the pump. you need to identify where the noise is coming from for a better diagnoses.
The ticking/buzzing noise is a common problem on the RX330. There is a plastic pin that is attached to the instument panel which inserts into a plastic housing on the firewall. This holds it in place to the firewall. It is a design problem that model year. In the 2006-models on have a piece of felt covering the plastic pin to reduce the vibration noise. The same noise can occur on the passenger side behind the glove box. You can try to access the white pin and stuff some felt/cloth, but it is difficult with out dissassembling the dash or glovebox.
how is the oil level and pressure?, how many miles on engine? is this a loud knock or rather a clatter/ticking noise? knock is engine rod or crankshaft bearings, clatter loud ticking is valve follower noise. how long before it (the noise) goes away?