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If this is the 4.3 liter the fuel pressure regulator is located in the intake valley. You will need to remove the upper half of the intake manifold, once removed you will see a small round regulator located at on end of the injector line.
Sounds like a top end repair of seals or a piston ring issue, or the intake manifold gaskets are leaking. With the age of the vehicle you may be able to go with the intake gasket first but if its the heads then you have to do it twice, and if its the rings allowing blow by you would have to take the heads off anyway. Just be careful so you get it narrowed down quick and easy check compression to see about blowby and the head may help.
For 2000 Chevrolet Truck Blazer
4WD 4.3L SFI 6cyl If your engine is a 4.3L V-6 with CPI (central point injection) it is
inside the upper intake manifold. The upper intake manifold is bolted on
top of the normal intake manifold.
The throttle body is mounted on
it and your fuel lines terminate into the center of this.
Removal & Installation
Relieve the fuel system pressure.
Remove the air cleaner outlet resonator.
Disconnect the engine wiring harness from the retaining clips at
the front of the engine.
Disconnect the fuel pressure regulator vacuum line.
Clean any dirt from the fuel pressure regulator and the
Disconnect the fuel return pipe.
Remove the fuel return pipe retainer.
Remove the fuel pressure regulator retainer.
Remove the fuel pressure regulator.
Inspect the regulator filter screen for contamination. If
contaminated, replace the fuel pressure regulator.
Fig. Fuel pressure regulator-4.2L engine
Install the regulator filter.
Install the new O-ring on the fuel pressure regulator.
Lubricate the fuel pressure regulator O-ring with clean engine
Push the fuel pressure regulator into the regulator housing on the
Install the fuel pressure regulator retainer. Tighten the
regulator retainer screw to 71 inch lbs. (8 Nm).
Install the fuel return pipe retainer. Tighten the return pipe
retainer screw to 71 inch lbs. (8 Nm).
Connect the fuel return pipe.
Connect the fuel pressure regulator vacuum line.
Connect the negative battery cable.
Inspect for leaks:
Turn ON the ignition for 2 seconds.
Turn OFF the ignition for 10 seconds.
Turn ON the ignition.
Inspect for fuel leaks.
Install the engine wiring harness into the retaining clips at the
front of the engine.
This fuel pressure regulator is a component part of the SFI (sequential fuel injection) assembly, sometimes referred to as "spider". It resides inside of the air intake plenum and is accessed by removing the upper half of the intake. Good luck and hope this helps. Most of the time when your having problems, it's most likely going to be the whole spider unit. GM has been know to have problems with this type of fuel injection system. Check the vacum line to the fuel pressure regulator at the back of the spider housing by the high pressure fuel line. You can see it just in front of the distributor cap and spider assembly.
the fuel pressure if leaking could cause this the regulator is located under the intake plenum but you should smell gas .if you dont then most likely the pump is bad ,the pump will come on for 2 seconds when the key is on then go off it will not stay on with just the key on only when you crank it will it .so have your fuel pressure checked with a gauge.